Breast cancer risk in relation to occupations with exposure to carcinogens and endocrine disruptors: A Canadian case-control study
Summary of the Research Findings
Breast cancer is the most commonly diagnosed cancer in Canadian women. Less than half of the cases can be explained by such commonly recognized risk factors as family or reproductive history. Breast cancer is likely caused by a combination of environmental, genetic, hormonal, and lifestyle influences. In industrialized countries, breast cancer incidence increased dramatically in the second half of the twentieth century as thousands of new chemicals with unknown health effects were being introduced and women were entering the workforce in record numbers. From advances in research we are learning about the relationship between chemical exposures and disease. It is believed that there is a complex interaction in the human body between cancer causing and hormone disrupting agents in which the endocrine system plays an important role. The exposure history of workers can generally be reconstructed with much greater accuracy than for the general population. Workers who are exposed occupationally can encounter much higher concentrations and therefore be at a greater risk for developing cancer. The purpose of this study performed in Windsor Ontario, Canada was to contribute to a better understanding of cancer causation, particularly for work-related breast cancer.
Background and Methods
This research was conducted in Essex and Kent counties in southern Ontario where there is extensive manufacturing and agriculture. Two previous smaller studies in this area found links between farming, work in the automotive industry and breast cancer risk. This study involved 1005 women with breast cancer and 1147 women without the disease who provided detailed occupational histories in order to describe potential exposures to carcinogens and endocrine disruptors. Participants also provided information on reproductive risk factors including number of pregnancies, history of breastfeeding, age at menstruation and menopause, as well as risk factors such as level of physical activity, alcohol use and smoking history.
A typical worker faces a toxic burden made up of multiple exposures to chemicals
from their paid employment, everyday environment, consumer products, and dietary
sources. Airborne exposures are of particular concern as women in the some
of the industries examined in this study are exposed to a "toxic soup" of chemicals.
Women's occupational health is often not considered by researchers and regulators
despite the fact that many are regularly exposed to cancer-causing agents and
endocrine disrupting chemicals that may increase their risk of developing breast
Carcinogens, Endocrine Disruptors & Windows of Vulnerability
- Carcinogens: There are several stages involved in the development of cancer including initiation, promotion and progression. The complex mixture of chemical exposures in the industrial workplace may have an impact on each of these stages.
- Endocrine Disrupting Chemicals: Synthetic chemicals can disrupt a variety of essential endocrine functions in the body. Disruption of the delicate hormone balance can result in reproductive disorders, immune system dysfunction, some cancers, birth defects, and neurological effects. In traditional toxicology a higher dose of a substance is expected to produce a greater effect. This is not necessarily the case with endocrine disrupting chemicals which can have health impacts even at very low levels.
- Windows of Vulnerability: The timing of chemical exposure
and stage of biological development can have an impact on a woman's risk of
developing breast cancer. Women are more susceptible to the effects of endocrine
disrupting chemicals before breast tissue is fully matured. This study considered
cumulative exposures during four critical windows: a) before menstruation,
b) menstruation to the first full term pregnancy, c) first full term pregnancy
to menopause, and d) after menopause.
Across all subjects in this study there was a statistically significant association of breast cancer incidence with work in jobs classified as high-exposed; 10 years of work in such jobs was estimated to increase breast cancer risk by 42 percent. For many specific sectors, with small numbers of women workers, there were too few people to show significant results, but for work in agriculture, metal-related manufacturing, automotive plastics, food canning operations, and casino work, statistically significant excesses were observed. Women who worked for ten years in jobs classified as highly exposed to cancer-causing substances and endocrine disrupting chemicals in the following occupational groups were found to have a higher risk for developing breast cancer:
- Farming: A 36 percent increased breast cancer risk (OR=1.36)
was found in the farming sector. Research has shown several pesticides act
as mammary carcinogens and many are endocrine disrupting chemicals. Employment
in farming and exposure to pesticides often begins earlier in women's lives
than other occupations and may play a role during subsequent windows of vulnerability.
- Plastics: A statistically significant more than 2-fold increased breast cancer risk was found in the automotive plastics industry sector (OR=2.68). The increase rose to an almost 5-fold excess among those who were pre-menopausal. Many plastics have been found to release estrogenic and carcinogenic chemicals and cumulative exposures to mixtures of these chemicals are a significant concern.
- Food Canning: A statistically significant 2-fold breast
cancer risk was found in the food canning sector (OR=2.35). The increase rose
to more than 5-fold among those who were pre-menopausal. Exposures to chemicals
in the food canning industry may include pesticide residues and emissions from
the polymer linings of cans. There has been little research conducted on women's
health in this industry.
- Metalworking: A statistically significant 73 percent increased breast cancer risk was found in the metalworking sector (OR=1.73). Women working in tooling, foundries, and metal parts manufacturing are exposed to a variety of potentially hazardous metals and chemicals. There has been little research conducted on breast cancer risk in this area, but this could have relevance for a broad range of blue-collar industrial operations.
- Bar/Casino/Racetrack: A 2-fold increased breast cancer risk approaching statistical significance was found in the bar/casino/racetrack sector (OR=2.28). The elevated risk of developing breast cancer may be linked to second-hand smoke exposure and night work which has been found to disrupt the endocrine system.
The occupational risks for breast cancer are a neglected area of research.
This study demonstrates the value of including detailed work histories in the
environmental and occupational epidemiology of breast cancer. Although exposures
to the myriad of specific agents in the work environment could not be individually
discerned for this study's population, the strong, significant associations
based on a generic classification imply the likelihood that carcinogens and
endocrine disrupting chemicals in these work environments increased breast
cancer risk. Resources should be aggressively allocated to preventing occupational
exposures to cancer-causing and endocrine disrupting chemicals linked to breast
cancer. Furthermore, women who have developed breast cancer from workplace
exposures should be compensated. To date no women in Canada from any of the
sectors identified in this study which pose an increased risk of breast cancer
have received worker compensation. These findings also have important implications
for the general public where exposures to similar agents may occur, albeit
at much lower levels. Because lower exposure levels may not be protective in
the case of carcinogens or endocrine disrupting chemicals, the findings point
to the need to re-evaluate the occupational and environmental exposure limits
established by government, keeping in mind that there may be no determinable
The full study, tables and references can be found on the websites of the
National Network on Environments and Women's Health (www.nnnewh.org), HealthyStuff.org,
the University of Windsor (www.uwindsor.ca/socanth), the Canadian Women's Health
Network (www.cwhn.ca), the University of Stirling (www.stir.ac.uk), and Environmental
Download complete study from HealthyStuff.org
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